Table 4.
Logistic Regression Models of Death and NDI by Infection Status
| Variable | Death | NDI | Death/NDI | |||
|---|---|---|---|---|---|---|
| Adj OR (95% CI) | p | Adj OR (95% CI) | P | Adj OR (95% CI) | p | |
| Infection Status: Candida vs. Groups from Candida Study | ||||||
| Candida vs. Uninfected (Candida study) | 4.76 (2.24, 10.14) | < 0.001 | 1.37 (0.72, 2.63) | 0.339 | 2.47 (1.47, 4.13) | 0.001 |
| Candida vs. LOS-Other | 1.62 (0.96, 2.75) | 0.073 | 0.79 (0.44, 1.43) | 0.441 | 1.19 (0.76, 1.85) | 0.457 |
| Candida vs. Clinical infection | 2.59 (1.47, 4.55) | 0.001 | 0.83 (0.45, 1.53) | 0.559 | 1.57 (0.99, 2.49) | 0.057 |
| Infection Status: Candida vs. Group from NRN registry | ||||||
| Candida vs. Uninfected (NRN registry) | 0.85 (0.51, 1.43) | 0.545 | 1.83 (1.01, 3.33) | 0.047 | 1.54 (0.99, 2.38) | 0.054 |
| Epoch 1 | 1.14 (0.88, 1.46) | 0.325 | 6.22 (4.59, 8.43) | < 0.001 | 3.35 (2.69, 4.17) | < 0.001 |
| Male | 2.08 (1.62, 2.67) | < 0.001 | 1.54 (1.19, 1.99) | 0.001 | 1.93 (1.57, 2.37) | < 0.001 |
| Birth weight < 750g | 5.41 (4.17, 7.02) | < 0.001 | 1.66 (1.27, 2.18) | < 0.001 | 3.20 (2.59, 3.95) | < 0.001 |
| Nonwhite race | 1.07 (0.84, 1.37) | 0.587 | 1.56 (1.21, 2.01) | 0.001 | 1.40 (1.14, 1.72) | 0.001 |
| High school or less | 1.84 (1.35, 2.52) | < 0.001 | 1.44 (1.12, 1.86) | 0.005 | 1.70 (1.35, 2.13) | < 0.001 |
| Postnatal corticosteroids | 1.19 (0.75, 1.89) | 0.452 | 2.24 (1.45, 3.45) | < 0.001 | 2.00 (1.36, 2.93) | < 0.001 |
| IVH/PVL | 4.84 (3.70, 6.31) | < 0.001 | 3.08 (2.19, 4.33) | < 0.001 | 5.45 (4.17, 7.10) | < 0.001 |
| NEC | 5.20 (3.38, 8.02) | < 0.001 | 1.26 (0.75, 2.12) | 0.377 | 2.82 (1.90, 4.18) | < 0.001 |
Note: Models also account for clustering of children within research centers. Model for NDI excludes children without data on NDI at follow-up. Reference categories are epoch 2, female, birth weight ≥ 750g, white race, more than high school education, did not receive postnatal steroids, did not have IVH/PVL, and did not have NEC. Areas under the ROC curve (AUC) for the models are: Death (AUC=0.83), NDI (AUC=0.77), and Death/NDI (AUC=0.80).