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Technical challenges of echocardiographic assessment of aortic valve function in mice.
| Limitation | Consequence |
|---|---|
| Limited 2-D resolution | M-mode required |
| Limited color Doppler frame rates | Underestimate aortic regurgitation |
| Lack of continuous-wave Doppler* | Pulse wave-derived valve gradients |
| Oversized pulse-wave gates | Overestimate aortic stenosis |
| Non-parallel signal alignment | Overestimate aortic stenosis |
When using ultra-high resolution instruments designed primarily for studies in mice.
