Table I.
Demographics, clinical data, and laboratory values for the patients included in the LIU score analysis (with peak INR) and for patients excluded from analysis because of missing laboratory values
| Included in calculating LIU (n = 461), No. (%) | Excluded in calculating LIU (n = 248), No. (%) | P | |
|---|---|---|---|
| Sex | |||
| Male | 229 (49.7) | 124 (50.0) | .93† |
| Female | 232 (50.3) | 124 (50.0) | |
| Median age (25%, 75%) | 5.5 (1.1, 13.5) | 3.8 (0.3, 13.3) | .02* |
| 0-<6 mo | 84 (18.2) | 72 (29.0) | .004† |
| 6 mo-<3 y | 93 (20.2) | 46 (18.6) | |
| ≥3 y | 284 (61.6) | 130 (52.4) | |
| Patients from outside hospital | 346 (75.2) | 211 (85.1) | .002† |
| Final diagnosis | |||
| Indeterminate | 230 (49.9) | 96 (38.7) | .08† |
| Acetaminophen overdose | 59 (12.8) | 35 (14.1) | |
| Metabolic | 40 (8.7) | 30 (12.1) | |
| Autoimmune | 24 (5.2) | 21 (8.4) | |
| Infection | 31 (6.7) | 19 (7.7) | |
| Other | 77 (16.7) | 47 (19.0) | |
| Outcome on day 21 | |||
| Alive without LT | 232 (50.3) | 166 (66.9) | <.0001† |
| LT | 167 (36.2) | 55 (22.2) | |
| Death without LT | 62 (13.4) | 27 (10.9) |
| Laboratory value | n, median (25%, 75%) | n, median (25%, 75%) | |
|---|---|---|---|
| Total bilirubin level, mg/dL | |||
| Admission | 441, 10.5 (3.2, 18.5) | 219, 9.6 (2.8, 16.5) | .16* |
| Highest value | 461, 13.3 (4.1, 21.4) | 229, 11.8 (3.1, 20.2) | .08* |
| PT, s | |||
| Admission | 391, 28.0 (23.0, 39.0) | 192, 25.3 (20.8, 33.7) | .002* |
| Highest value | 402, 33.3 (25.1, 45.5) | 196, 28.9 (21.4, 39.0) | .0003* |
| INR | |||
| Admission | 449, 2.8 (2.1, 4.3) | 168, 2.7 (2.0, 3.9) | .04* |
| Highest value | 461, 3.6 (2.5, 5.4) | 171, 2.9 (2.1, 4.5) | .0004* |
| Ammonia level, μmol/L | |||
| Admission | 412, 71.5 (44.0, 116.0) | 56, 55.0 (37.5, 92.0) | .04* |
| Highest value | 461, 90.0 (57.0, 135.0) | 67, 57.0 (41.0, 97.0) | .0002* |
*
Wilcoxon rank sum test.
†
χ2 Test.