Diagram demonstrating the mechanism of acetylcholine synthesis, release, action and breakdown at a cholinergic nerve terminal. ACh Acetylcholine, ChAT choline acetyltransferase, CHT1 highaffinity choline transporter-1, VAChT vesicular ACh transporter, AChE acetylcholinesterase, BChE butyrylcholinesterase, mAChR muscarinic receptors and nAChR nicotinic receptors (Adapted from Kummer et al. [72])