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. 2013 Sep 30;4:127. doi: 10.3389/fendo.2013.00127

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Copyright © 2013 Durán-Pastén and Fiordelisio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of a gonadotroph illustrating the main control pathways of gonadotropin synthesis and secretion. GnRH, gonadotropin-releasing hormone; Gq, protein Gq/₁₁; PLCβ, phospholipase C; PIP2, phosphatidylinositol 4,5 bisphosphate; DAG, diacylglycerol; IP₃, inositol 1,4,5-trisphosphate; PKC, protein kinase C; VGCC, voltage-gated calcium channels; CaMKII, calcium calmodulin type II kinase; RE pump, endoplasmic reticulum Ca²⁺ pump; PM pump, plasma membrane Ca²⁺ pump; SK, small conductance calcium-activated potassium channels; P, progesterone; PR, progesterone receptor; E, estradiol; ERα, estrogen receptor α; T, testosterone; AR, androgen receptor; Raf, serine/threonine kinase; MEK, mitogen-activated protein kinase; ERK, extracellular-signal-regulated kinases.