Table 2. Summary of findings in 6 groups of mice.
| WT | WT + 5-HT | SERT-KO | SERT-KO + 5-HT | TPH1-KO | TPH1-KO + 5-HT | |
|---|---|---|---|---|---|---|
| [5-HT] in plasma (ng/μl blood) | 0.85 ± 0.04 | 2.74 ± 0.37 | 1.75 ± 0.05 | 3.54 ± 0.16 | u.n.d. | 2.14 ± 0.4 |
| [5-HT] in platelet (ng/μl blood) | 5.15 ± 0.89 | 5.77 ± 0.54 | u.n.d. | u.n.d. | u.n.d. | 4.97 ± 0.5 |
| 5-HT uptake rates (pmol/min/mg protein) | 0.76 ± 0.08 | 0.48 ± 0.05 | u.n.d. | u.n.d. | 0.89 ± 0.04 | 0.45 ± 0.08 |
| Percent aggregation rate | 35.8 ± 8.06 | 70.7 ± 7.63 | 25.67 ± 5.03 | 34.67 ± 4.16 | 31.67 ± 5.77 | 60 ± 3.54 |
| Flow Cytometry analysis of P-selectin | 181.7 ± 8.00 | 316.05 ± 2.61 | 96.15 ± 9.76 | 105.46 ± 11.8 | 93.13 ± 7.77 | 195.38 ± 13.11 |
| Ratio Neu5Gc/Neu5Ac (LC-MS results) | 0.61 ± 0.04 | 1.73 ± 0.3 | 0.68 ± 0.03 | 3.88 ± 0.32 | 0.43 ± 0.07 | 2.13 ± 0.24 |
u.n.d. = undetectable; defined as [5-HT] < 0.1 ng/ml or 5-HT uptake rate less than the background accumulation of 3H-5HT.