Table 1.
Microspheres | Copolymer composition | Initial molecular weight (g/mol)a | Amount of drug incorporated (mg) | Inherent viscosity dL/g (manufacturer) |
---|---|---|---|---|
PDLLGA-90:10-0 | 90:10 | 120,778 | 0 | 0.85 (Birmingham Polymers, Inc.) |
PDLLGA-90:10-200 | 90:10 | 120,778 | 200 | 0.85 (Birmingham Polymers, Inc.) |
PDLLGA-90:10-200 | 90:10 | 85,415 | 200 | 0.64 (Birmingham Polymers, Inc.) |
PDLLGA-90:10-200 | 90:10 | 66,572 | 200 | 0.54 (Birmingham Polymers, Inc.) |
PDLLGA-90:10-0 | 90:10 | 80,145 | 0 | 0.20 (Polysciences, Inc.) |
PDLLGA-90:10-200 | 90:10 | 80,145 | 200 | 0.20 (Polysciences, Inc.) |
PDLLGA-65:35-0 | 65:35 | 30,600 | 0 | 0.42 (Birmingham Polymers, Inc.) |
PDLLGA-65:35-200 | 65:35 | 30,600 | 200 | 0.42 (Birmingham Polymers, Inc.) |
PDLLGA-50:50-0 | 50:50 | 28,960 | 0 | 0.61 (Birmingham Polymers, Inc.) |
PDLLAGA-50:50-200 | 50:50 | 28,960 | 200 | 0.61 (Birmingham Polymers, Inc.) |
Determined using GPC when the copolymers were received.