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. Author manuscript; available in PMC: 2013 Sep 30.
Published in final edited form as: Transfusion. 2012 Sep 25;53(6):1309–1318. doi: 10.1111/j.1537-2995.2012.03903.x

Fig. 5.

Fig. 5

A conventional HPA-1a antibody clears PLTs more efficiently when injected IV than when given IP. Human PLTs were transfused to NOD/SCID mice followed by IV or IP injection of a conventional HPA-1a antibody. At 24 hours, PLT survival was shortened when antibody diluted 1/50 was given IV but not when the same quantity of antibody was given IP (p < 0.01). Five times as much antibody (1/10) given IP caused PLT clearance comparable to a smaller amount (1/50) given IV. Values shown are average of multiple determinations ±1.0 SD. Shaded gray area depicts range of PLT survival at 24 hours after injection of normal serum (mean ± 2.0 SD).