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. Author manuscript; available in PMC: 2013 Sep 30.
Published in final edited form as: J Pain. 2012 Apr 5;13(6):524–531. doi: 10.1016/j.jpain.2012.01.006

Figure 2.

Figure 2

IB4 (+) and IB4 (−) neurons in OSCC-induced nociceptive behaviors. A. OSCC-induced mechanical allodynia was attenuated by DOR selective agonist SNC80 and P2X3 antagonist TNP-ATP. The effect of SNC80 was blocked by coadministration of DOR selective antagonist naltrindole (NTI). Note that anti-NGF was also effective in blocking OSCC-induced mechanical allodynia. Removal of IB4 (+) neurons by IB4-SAP significantly abolished OSCC-induced mechanical allodynia. B. SNC80 or TNP-ATP was not effective against thermal hyperalgesia. In contrast, anti-NGF significantly blocked OSCC-induced thermal hypersensitivity. Removal of IB4 (+) neurons by IB4-SAP showed no effect on OSCC-induced thermal hyperalgesia. IB4-SAP and SAP treated mice exhibited similar reduction after OSCC-supernatant injection. *P<0.05; **P<0.01; ***P<0.001, groups were compared with OSCC-supernatant injection alone. # P<0.05; IB4-SAP vs. SAP treatment group.