Table I.
Genes associated with tumor development
| Gene | Gene name | Maximal fold changes | Type | Proliferation | Apoptosis | Invasion | Metastasis | Migration | Thyroid cancer |
|---|---|---|---|---|---|---|---|---|---|
| Up-cluster | |||||||||
| Lcn2 | Lipocalin 2 | 55.02 | I | * | * | * | * | * | |
| Tgfbi | Transforming growth factor, beta-induced, 68kDa | 22.5 | I | * | * | * | * | ||
| Serpinf1 | Serpin peptidase inhibitor, clade F, member 1 | 9.33 | I | * | * | * | * | ||
| Anxa1 | Annexin A1 | 9.21 | I | * | * | * | * | * | |
| Fn1 | Fibronectin 1 | 8.05 | I | * | * | * | * | * | * |
| Lbp | Lipopolysaccharide binding protein | 7.84 | I | * | |||||
| Ltf | Lactotransferrin | 5.95 | I | * | * | * | * | ||
| Camk1d | Calcium/calmodulin- dependent protein kinase ID | 5.07 | I | * | * | ||||
| Igf1 | Insulin-like growth factor 1 | 4.41 | I | * | * | * | * | * | |
| Smarcb1 | SWI/SNF-related matrix-associated actin-dependent regulator chromatin, subfamily b, member 1 | 4.26 | II | * | * | * | |||
| Vim | Vimentin | 4.16 | II | * | * | * | * | * | * |
| Col18a1 | Collagen, type XVIII, alpha 1 | 3.99 | I | * | * | * | * | * | |
| Grn | Granulin | 3.82 | II | * | * | * | * | ||
| Lamc1 | Laminin, gamma 1 | 3.7 | I | * | * | * | |||
| Col4a1 | Collagen, type IV, alpha 1 | 3.67 | I | * | * | * | * | ||
| Ehf | Ets homologous factor | 3.61 | II | * | * | ||||
| Tyms | Thymidylate synthetase | 3.6 | II | * | * | * | |||
| Nr2f2 | Nuclear receptor subfamily group F, member 2 | 3.56 | II | * | * | ||||
| Ucp2 | Uncoupling protein 2 | 3.53 | I | * | * | * | |||
| Bgn | Biglycan | 3.38 | I | * | * | * | |||
| Tfrc | Transferrin receptor | 3.28 | I | * | * | ||||
| Col3a1 | Collagen, type III, alpha 1 | 3.2 | II | * | |||||
| Ptn | Pleiotrophin | 3.1 | II | * | * | * | * | ||
| Down-cluster | |||||||||
| Agr2 | Anterior gradient 2 homolog | 0.5 | I | * | |||||
| Esr1 | Estrogen receptor 1 | 0.5 | II | * | * | * | * | * | |
| Smo | Smoothened frizzled family receptor | 0.49 | I | * | * | * | * | ||
| Pcm1 | Pericentriolar material 1 | 0.49 | I | * | |||||
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.48 | I | * | * | ||||
| Flrt2 | Fibronectin leucine rich transmembrane protein 2 | 0.47 | I | * | |||||
| Anxa5 | Annexin A5 | 0.46 | II | * | * | * | |||
| Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.45 | I | * | * | * | * | ||
| Prlr | Prolactin receptor | 0.38 | I | * | * | * | * | ||
| Lmo7 | LIM domain 7 | 0.38 | I | * | * | ||||
| Timp3 | TIMP metallopeptidase inhibitor 3 | 0.34 | II | * | * | * | * | * | |
| Tacstd2 | Tumor-associated calcium signal transducer 2 | 0.32 | I | * | |||||
| Timp4 | TIMP metallopeptidase inhibitor 4 | 0.31 | II | * | * | * | |||
| Fasn | Fatty acid synthase | 0.31 | I | * | * | ||||
| Txnip | Thioredoxin interacting protein | 0.29 | I | * | * | * | |||
| Maximal fold changes (bold values): the ratio of highest value versus lowest value at five selective time points in mice aged from 3 weeks to 14 months. | |||||||||