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Correlation of the TrxR inhibitory and antiproliferative potencies of Michael acceptor moiety-bearing compounds. The in vitro 50% TrxR inhibition concentration (IC50) values of 4-, 6-, and 3-Ph-3-SG, as well as the DPPen and DPPro analogs were plotted against their corresponding 50% growth inhibition concentration (GI50) values obtained in HCT 116 cells. The DPPen and DPPro analogs, but not the shogaols (SGs), showed a positive correlation with the linear correlation coefficient r=0.81.
