Table 1. Contrasting features of a selection of myofibrillogenesis computation models.

Model property	Novak et al. (2004)	Deshpande et al. (2006, 2008)	Paszek et al. (2009)	Grosberg et al. (2011)
Model type	Phenomeno-logical	Finite element/solid mechanics	Chemo-mechanical	Phenomeno-logical
Model compared to cell type	NIH3T3 fibroblasts (Brock et al. 2003)	Retinal pigment epithelial human cells or fibroblast cells	No specific cell type	Neonatal rat ventricular myocytes
Integrins have a free and bound state (or high/low affinity)	Yes	Yes	Yes	Yes
Focal adhesions more stable with greater force	Yes	Yes	Yes	Yes
Myofibrils/stress fibers	Yes	Ye s	No	Yes
included in model Fiber length-force dependence	No	Not explicitly	No	Yes
Differentiating between pre-myofibril and nascent myofibril formation	No	No	N/A	Yes
Myofibril actively mutually align	No	No	N/A	Yes
Testing boundary conditions/symmetry breaking	No	No	No	Yes
Detailed model of solid mechanics of the interface	No	Yes	Yes	No
Substrate mechanical load	No	Yes, but not the deformation of the substrate	Yes and Detailed, i.e. both stress and strain—deformation	Yes, but very simply (only traction)
Computationally complex	No	Yes	Yes	No