Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Bioorg Med Chem. 2013 Jun 15;21(17):5373–5382. doi: 10.1016/j.bmc.2013.06.012

Table 2.

SAR by purchase for the Maybridge Hit XAX-164

graphic file with name nihms494587u1.jpg
Name R1 EC50 S1PR2 (μM) Max Activity (% of 1 μM S1P)
2 (XAX-164) 4-clorophenyl 1.3 80%
3 (XAX-162) 4-methylphenyl 0.55 130%
4 (XAX-166) 4-bromophenyl 0.82 80%
5 (XAX-159) 6-(trifluoromethyl)pyridin-2-yl >10 30%
6 (XAX-160) Cyclohexyl >10 20%
graphic file with name nihms494587u2.jpg
Name R2 EC50 S1PR2 (μM) Max Activity (%of 1 μM S1P)
7 (BTB06747) Carboxyl >10 0%
8 (CD05115) Cl >10 0%