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Synthesized SAR compounds
| Name | Structure | EC50 S1PR2 (μM) | Max Activity (%of 1 μM S1P) |
|---|---|---|---|
| 1 (CYM-5482)α |
|
1.03 | 95% |
| 9 (CYM-5477) |
|
>10 | 35% |
| 10 (CYM-5478) |
|
0.78 | 100% |
| 11 (CYM-5491) |
|
>10 | 9% |
| 12 (CYM-5481) |
|
>10 | 10% |
| 13 (CYM-5473) |
|
>10 | 0% |
| 14 (CYM-5520) |
|
0.48 | 100% |
Resynthesized original hit.
