Table 6.
Case Illustrations. Abbreviations of CTSA key resources used: BS = biostatistics; BioIT = bioinformatics; CC = coordination; ED = education; Edit = editorial support; Eth = ethics; NM = novel methodologies; Reg = regulatory; T&E = tracking and evaluation, TT = translational technologies
| Developmental Stage (Figure 2) | Severe Asthma – SAMTT | Clostridium difficile infection CDI‐MTT |
|---|---|---|
| Identification of Opportunity/Need | • Purpose: identify protein biomarker of severe asthma | • Purpose: develop novel therapeutic for CD infection/colitis |
| • Opportunity to leverage current UTMB assets by incorporating CTSA resources | • Basic science research in CD infection identified ‐mechanism of virulence | |
| • Molecular phenotyping is of considerable interest in academic asthma community | • Small molecule inhibitor of toxin defined | |
| • CTSA Help: Opportunity recognition | • CDI is important source of morbidity and mortality in USA and globally | |
| • CTSA KRs: CC, Pilot | • CTSA Help: guidance on MTT creation | |
| • CTSA KRs: CC | ||
| Team/Network Establishment | • Initiation: Working group in place; team development embryonic. | • Initiation: MTT goals established, and necessary expertise determined |
| • Team members with expertise in biostatistics, ethics, and informatics were added. | • Expertise in biostatistics, regulatory affairs, ethics, and clinical medicine, and trial design was embedded | |
| • Trainee positioned as project manager | • Team development had not begun | |
| • Team development coach necessary | • CTSA Help: Team development, logistics and scheduling; goal setting; leadership development | |
| • CTSA Help: Team development, trainees; goal setting; leadership development | • CTSA KRs: CC, Eth, BS, Reg, ED, NM, Pilot | |
| • CTSA KRs: CC, Eth, BS, ED | ||
| Team Orientation | • Barriers: Nonoverlapping expertise inhibited communication | • Barriers: New team required advice and support in many areas |
| • “Method Intuition” seminars to improve cross disciplinary communications | • TSA resources provided rapid start‐up of the MTT | |
| • Metrics, benchmarks, milestones | • Facilitated team development | |
| • CTSA Help: Logistics, scheduling, process | • Regulatory KR completed submission of a necessary IND | |
| • CTSA KRs: CC, BioIT, T&E, ED, Eth | • CTSA Help: Logistics, scheduling, | |
| • CTSA KRs: CC, Reg | ||
| Collaboration/ Exchange/Engagement | • Early outcomes: Two manuscripts published in field of molecular phenotyping | • Early Outcomes: Definition of S‐NO in toxin inactivation; Metabolomic analysis initiated as parallel project: identify metabolomic signature of CDI infection |
| • Incorporation of visual analytics added important mechanistic insights | • CTSA Help: Grant administration | |
| • CTSA Help: Edit | • CTSA KRs: CC, NM, TT | |
| • CTSA KRs: CC, BioIT, BS, |