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. 2013 Jul 11;5(3):e00117. doi: 10.1042/AN20130002

Figure 4. Effect of calpain inhibitor calpeptin on PT-induced brain infarction and neuronal death.

Figure 4

(A) Nissl stained images of brain sections from the regions with maximum infarction under different conditions, i.e. mice subject to PT (group 1, left), PT with administration of MPEP/LY367385/calpeptin (group 2, middle) and PT with administration of calpeptin (group 3, right). (B) Summary of infarct volumes. N=21 mice for group 1, N=4 mice for groups 2 and 3. (C,D) Representative images of FJB staining (C) and summary of the densities of FJB+ cell (D). (E,F) Representative images of TUNEL staining (E) and summary of the densities of TUNEL+ cell (F). N=4 mice for groups 1–3 in (D)–(F). *P<0.05, ns-no significant difference, ANOVA test.