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. Author manuscript; available in PMC: 2013 Sep 30.
Published in final edited form as: Curr Drug Targets. 2011 Apr;12(4):546–555. doi: 10.2174/138945011794751528

Figure 2. ATP-binding clefts of Jak kinase domain structures.

Figure 2

Comparison of the ATP-binding clefts and bound small molecules for all Jak family kinase domain crystal structures. In these structures the kinase nucleotide-binding glycine-rich loop (P-loop) has been trapped in multiple conformations, describing its flexibility. Additionally, in four of the Jak2 structures (3JY9, 3KCK, 3IOK, 3IO7) the P-loop is not visible in the electron density, indicating significant flexibility within these crystals. Jak1 is colored cyan, Jak2 in green, Jak3 in orange and Tyk2 in magenta. The protein data bank accession code is indicated for each structure. If two molecules exist in the crystal structure with different conformations these are indicated by parentheses.