Table 3.
Association of weekly alcohol consumption with PSA and prostate cancer risk
| 1st third (0.1–9.8 units/week) | 2nd third (9.9–19.7 units/week) | 3rd third(19.8–112 units/week) | Dose-response1 | ptrend | P2 | |
|---|---|---|---|---|---|---|
| PSA levels–controls only3 (11,086 controls) | 1 | 0.97 (0.94; 1.01) | 0.92 (0.89; 0.95) | 0.98 (0.98, 0.99) | <0.001 | – |
| Total prostate cancer4 (2,083 cases) | 1 | 0.94 (0.84; 1.06) | 0.92 (0.82; 1.04) | 0.99 (0.96; 1.01) | 0.347 | – |
| Localized stage prostate cancer5 (1,676 cases) | 1 | 0.97 (0.85; 1.09) | 0.93 (0.81; 1.05) | 0.99 (0.96; 1.02) | 0.573 | – |
| Advanced stage prostate cancer5 (178 cases) | 1 | 0.87 (0.61; 1.25) | 0.86 (0.59; 1.23) | 0.95 (0.87; 1.04) | 0.238 | 0.338 |
| Low-grade prostate cancer5 (1,400 cases) | 1 | 0.97 (0.85; 1.11) | 0.84 (0.73; 0.96) | 0.96 (0.93; 0.99) | 0.017 | – |
| High-grade prostate cancer5 (675 cases) | 1 | 0.86 (0.71; 1.05) | 1.11 (0.92; 1.34) | 1.04 (0.99; 1.08) | 0.094 | 0.004 |
Analysis of 2,083 cases and 11,086 controls who were drinking alcohol at the time of assessment.
Per 10 units/week increase.
Test for difference in the effect-estimates for localized versus advanced and low-grade versus high-grade prostate cancer.
Ratios of geometric means and 95% confidence intervals from linear regression, adjusted for the design variables on which controls and cases were matched–additionally adjusted for age as continuous variable.
Odds ratios and 95% confidence intervals from conditional logistic regression models, additionally adjusted for age as a continuous variable.
Relative risk ratios and 95% confidence intervals from logistic regression, adjusted for the design variables on which controls and cases were matched—additionally adjusted for age as continuous variable. For definitions of localized/advanced stage and low/high-grade, see methods section. Abbreviations PSA, prostate-specific antigen.