Table 1.

Mice characteristics

Genotype	Number (n)	Diet	Antibiotics (mg/kg/day)	Body weight (g)		Energy intake (kcal/day)	Fat intake (LCT, μmol/day)	Fecal excretion (g/day)	Fecal fat excretion (LCT, μmol/day)	Net fat uptake (LCT, μmol/day)	Fat absorption (%)
				Pretreatment	Post-treatment
Δ/Δ	4	Chow	M: 103 ± 20	22.8 ± 1.6	22.0 ± 0.6	16.8 ± 1.1	559 ± 38	0.88 ± 0.15	40.0 ± 5.5	519 ± 37	92.1 ± 1.2
			C: 51 ± 10
	4	Chow	Control	24.1 ± 4.1	24.6 ± 4.7	18.8 ± 1.4	627 ± 46	1.02 ± 0.03	55.8 ± 8.6	571 ± 39	90.2 ± 1.0
+/+	4	Chow	M: 92 ± 9	25.1 ± 3.8	26.0 ± 3.6	18.8 ± 1.5	629 ± 49	0.92 ± 0.07	54.8 ± 3.2	574 ± 48	90.3 ± 0.9
			C: 46 ± 5
	4	Chow	Control	25.2 ± 3.9	27.0 ± 5.0	19.5 ± 4.2	653 ± 140	0.96 ± 0.04	55.0 ± 2.3	598 ± 141	90.2 ± 2.8
−/−	12	Liquid	M: 93 ± 13	5.2 ± 1.1	19.2 ± 2.1*	14.0 ± 2.0	313 ± 44	0.14 ± 0.06	10.6 ± 7.0	302 ± 43	96.7 ± 2.0
			C: 47 ± 7
	5	Liquid	Control	6.5 ± 0.5	15.4 ± 2.5	14.5 ± 1.1	325 ± 25	0.15 ± 0.03	13.1 ± 3.1	312 ± 28	95.9 ± 1.3
+/+	12	Liquid	M: 105 ± 13	7.6 ± 0.7	21.1 ± 2.8	15.8 ± 1.9	355 ± 44	0.14 ± 0.07	3.7 ± 1.7	351 ± 44	99.0 ± 0.5
			C: 53 ± 7
	5	Liquid	Control	7.2 ± 0.2	20.3 ± 2.0	15.4 ± 3.2	345 ± 72	0.11 ± 0.02	3.1 ± 0.7	342 ± 72	99.0 ± 0.3

Nutritional data of homozygous ΔF508 mice (Δ/Δ) (FVB/129 genetic background), CFTR-knockout mice (−/−) (C57Bl/6/129 genetic background), and wild-type littermates (+/+) after AB or control treatment. Except for body weight in the AB-treated −/− mice, no differences were observed between the AB and control-treated mice of the same genetic background (Mann–Whitney test). The ingested amount of AB was similar between all groups (Kruskal–Wallis test). Values are depicted as mean ± SD.

AB, antibiotic; C, ciprofloxacine; CFTR, cystic fibrosis transmembrane conductance regulator; LCT, long-chain triglycerides; M, metronidazole.

^*P < 0.05.