Table 2.

Multiple regression analysis in CFTR-knockout mice and WT littermates

Dependent variables	Independent variables	B	P value	R2 total model
Fat malabsorption (total)	Genotype (WT = 0)	2.5	<0.001a	0.53
	Treatment (control = 0)	−0.38	0.47
	Gender (female = 0)	0.59	0.23
Fat malabsorption (saturated)	Genotype (WT = 0)	7	<0.001a	0.6
	Treatment (control = 0)	−1.8	0.16
	Gender (female = 0)	1.5	0.21
Fat malabsorption (unsaturated)	Genotype (WT = 0)	0.77	0.001	0.33
	Treatment (control = 0)	0.17	0.47
	Gender (female = 0)	0.19	0.42
Fecal bile salt excretion (total)	Genotype (WT = 0)	10.8	<0.001a	0.54
	Treatment (control = 0)	−12.1	<0.001a
	Gender (female = 0)	−5.7	0.06
Fecal bile salt excretion (primary)	Genotype (WT = 0)	7.8	<0.001a	0.47
	Treatment (control = 0)	−3.2	0.09
	Gender (female = 0)	−0.6	0.7
Fecal bile salt excretion (secondary)	Genotype (WT = 0)	1.4	0.4	0.38
	Treatment (control = 0)	−6.2	0.003a
	Gender (female = 0)	−4.9	0.014a
Body weight	Genotype (WT = 0)	−3.8	<0.001a	0.71
	Treatment (control = 0)	−0.9	0.44
	Gender (female = 0)	0.8	0.51
	Gender × treatment	3.6	0.02a

B, unstandardized β coefficient; CFTR, cystic fibrosis transmembrane conductance regulator; R², regression correlation coefficient; WT, wild-type.

^aStatistically significant.