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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Nat Neurosci. 2013 Jul 21;16(9):1331–1339. doi: 10.1038/nn.3464

Figure 8. Effect of glutamatergic antagonists on the Vm of L2/3 neurons during stationary and locomotion periods.

Figure 8

(a) Vm (top trace) recordings during stationary and locomotion periods (bottom trace) before (left), during (blue box) and after (right) local injection of 1mM AMPA and NMDA antagonists CNQX and AP5. (b) Tonic depolarization of the Vm (top trace) during locomotion episodes (bottom trace) during blockade of the spontaneous activity by CNQX and AP5 in another neuron. (c) Recording of the Vm (middle trace) of a third neuron during the transition between stationary and locomotion (bottom trace) while visual stimuli are presented (top trace). (d)) Plot of the difference between the locomotion Vm and stationary Vm during baseline and during glutamatergic blockade (n = 6 neurons from 6 mice). Solid circles indicate mean ±s.e.m. The decrease in locomotion depolarization during glutamatergic blockade is significant (Mann-Whitney U Test, p = 0.009).