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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Thromb Haemost. 2013 Feb 7;109(3):407–415. doi: 10.1160/TH12-09-0678

Figure 2. Cross talk between transcellular trafficking and paracellular junctional complexes.

Figure 2

Caveolae fission and loss of Cav-1 enhancee NOS mediated NO production. Nitrosylation of p190RhoGAP impairs inhibition of RhoA, resulting in stress fiber formation, junctional instability, and increased paracellular permeability. Direct nitrosylation of junctional proteins may also regulate junctional disassembly.