Fig. 2.
Epileptogenesis in mouse organotypic hippocampal slices. (A–B) Extracellular field potential recordings in the CA3 pyramidal cell layer in organotypic hippocampal slices at DIV 7 (A) and DIV14 (B). Electrical recordings revealed spontaneous epileptiform discharges, including interictal epileptiform discharges (IEDs) and ictal-like seizure activity. (C) Group data from 70 recordings (2–3 hours in each recording) from 70 organotypic hippocampal slices (n = 10 slices in each age group).