Fig. 4.

Responses of G3 founders in a forward genetic screen that had reproducibly abnormal ERG responses. None of at least 20 G5F2 offspring of each of these mice were affected. It is possible that these mice either had a disease or injury that was not revealed by fundoscopy or that the abnormal ERG resulted from mutations in more than one gene. The classifications that are used in this figure are arbitrary and are included only to call attention to a distinguishing feature of the abnormal ERG. The mouse with the large a-wave (lower left) is one of two G3 siblings whose a-wave amplitude (see supplementary Tables I and II) was more than 2 SD greater than the mean. Neither sibling’s phenotype was observed in the G4F2 mice. Each of these abnormal phenotypes was recorded a second time (see Supplementary Fig. 1)