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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Mayo Clin Proc. 2013 Aug;88(8):884–898. doi: 10.1016/j.mayocp.2013.05.003

Figure 1. Pluripotent stem cell derived cardiac patches.

Figure 1

A) Vascularization of cardiac patches based on cardiomyocytes (CM) derived from human embryonic stem cells (hESC) can be enhanced by co-culture with endothelial cells (EC) and either mouse embryonic fibroblasts (MEFs) or mesenchymal stem cells (MSC). B) Human iPSC based cardiac patch can be implanted onto the heart of an athymic rat and persist for one week. Top β-myosin heavy chain staining; bottom, α-actinin, showing the graft–host interface. From Circ Res,62 with permission. CM= cardiomyocytes; EC = endothelial cells; MEFs = mouse embryonic fibroblasts; MSC = mesenchymal stem cell.