Figure 5. Transcoronary delivery of alginate.

Alginate, which is crosslinked with Ca²⁺, was delivered via a catheter-based transcoronary infusion in a porcine MI model. Given the leaky vasculature and high extracellular Ca²⁺ in an acute MI, the material is able to pass through the vasculature and gel once inside the tissue. The white material is visible on the epicardial surface of the infarct (A) and in tissue slices (B). From JACC,¹¹⁰ with permission.