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. Author manuscript; available in PMC: 2013 Sep 30.
Published in final edited form as: Inflamm Bowel Dis. 2010 May;16(5):743–752. doi: 10.1002/ibd.21148

Figure 7. Corticosteroid therapy attenuated ileitis, decreased lymphoid organ cellularity and TH1 cytokine transcripts in ilea of SAMP1 mice.

Figure 7

(A & B) Dexamethasone administration (100μg, I.P., Q.O.D. over 8 days) attenuated disease indices and restored intestinal architecture in 11-week-old SAMP1 mice compared to age-matched saline-treated (vehicle) controls. (C) The cellularity of the MLN and spleen as well as (D) IFN-γ and TNF ileal mRNA expression were additionally decreased. Target cytokines were normalized to 18S ribosomal RNA. Data expressed as means ± SEM, *P<0.05, **P<.01, ***P<.001 vs. age-matched AKR control, ++P<.01 vs. Vehicle treated SAMP1. Scale bars represent 100μm (A & C; n=6–7, D; n=3)