. 2013 Jun 20;6(2):355–360. doi: 10.3892/etm.2013.1171

Table IV.

Correlation between responses of tumor markers and effectiveness of different chemotherapy regimens.

Regimen	CR + PR	NC + PD	t-value	P-value
NO
CEA	25	36	3.953	<0.001^a
CYFRA 21-1	17	29	2.838	0.007^a
CA 19-9	21	25	2.178	0.039^a
CA 125	21	30	2.361	0.025^a
NSE	19	22	1.303	0.200
TP
CEA	34	39	4.889	<0.001^a
CYFRA 21-1	32	30	3.975	<0.001^a
CA 19-9	24	26	2.290	0.026^a
CA 125	32	32	1.952	0.059
NSE	23	21	1.571	0.124
GP
CEA	25	27	1.912	0.062
CYFRA 21-1	22	20	2.419	0.020^a
CA 19-9	21	22	1.004	0.327
CA 125	22	25	0.968	0.338
NSE	20	18	3.003	0.004^a
PP
CEA	21	26	3.813	<0.001^a
CYFR 21-1	20	17	2.715	0.010^a
CA 19-9	18	20	2.563	0.015^a
CA 125	10	19	1.201	0.238
NSE	16	12	1.286	0.224
TKI
CEA	5	22	4.696	<0.001^a
CYFRA 21-1	6	21	4.219	<0.001^a
CA 19-9	5	20	0.656	0.519
CA 125	5	19	2.424	0.024^a
NSE	6	16	1.492	0.151

P<0.05. NO, surgery only; TP, paclitaxel or docetaxel; GP, gemcitabine; PP, pemetrexed; TKI, tyrosine kinase inhibitor; CEA, carcinoembryonic antigen; CYFRA 21-1, cytokeratin 19 fragment; CA, carbohydrate antigen; NSE, neuron-specific enolase; CR, complete response; PR, partial response; NC, no change; PD, progressive disease.