Mean (±SE) weight loss (in kg) in participants in Enhanced Brief Lifestyle Counseling who chose at the start of the trial to use sibutramine, meal replacements, or orlistat as their enhancement. (Participants may have changed enhancements during the study.) At months 6, 12, and 18, groups with different superscripts (i.e., a, b, c) differ significantly (p ≤ 0.05) from each other.