Table 3.

A summary of the three POWER trials.

Study	N	Interventions	Number of treatment visits	Months of post-randomization follow-up	Weight change at month 6, kg	Weight change at follow-up, kg	≥ 5% loss of initial weight at follow-up, % of subjects	Attrition at follow-up, %*
Wadden et al.4	390	1) Usual care	8	24	−2.0 ± 0.5a	−1.7 ± 0.7a	21.5a	15
		2) Brief lifestyle counseling (quarterly PCP visits + MA counseling)	33	24	−3.5 ± 0.5b	−2.9 ± 0.7ab	26.0ab	15
		3) Enhanced brief lifestyle counseling (quarterly PCP visits + MA counseling + meal replacements/medication)	33	24	−6.6 ± 0.5c	−4.6 ± 0.7b	34.9b	12
Bennett et al.5	365	1) Usual care	0	24	−0.1 ± 0.4a	−0.5 ± 0.4a	19.5	10
		2) Telephone + electronic-based + group counseling	30	24	−1.3 ± 0.4b	−1.5 ± 0.4b	20.0	18
Appel et al.6	415	1) Control (self-directed)	2	24	−1.4 ± 0.4a	−0.8 ± 0.6a	18.8a	7
		2) Remote support only (telephone + electronic-based counseling)	33	24	−6.1 ± 0.5b	−4.6 ± 0.7b	38.2b	5
		3) In-person support (telephone + electronic-based + in-person counseling)	57	24	−5.8 ± 0.6b	−5.1 ± 0.8b	41.4b	4

Note: Values shown for weight change are mean ± SEM. For each study, under “weight change” (at month 6 and at follow-up) and “ ≥5% loss of initial weight at follow-up,” values labeled with different letters (a,b,c) are significantly different from each other at p < 0.05; PCP = primary care provider; MA = medical assistant.

^*Attrition is defined as the percentage of participants who did not contribute an in-person weight at the end of the study. An intention-to-treat analysis was used in these studies.

^**Weight losses represent percentage weight change.