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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Immunol. 2012 Oct 19;189(11):5185–5193. doi: 10.4049/jimmunol.1102952

Figure 2.

Figure 2

Marked reduction of anergic B cells in Bcl10-deficient mice and increased apoptosis of the mutant anergic B cells. A, Splenic B cell subpopulations. Splenocytes from wild-type and Bcl10-deficient mice were stained with antibodies to B220, CD93, IgM, and CD23. In B220+CD93+-gated cells, T1 (CD23-IgMhi), T2 (CD23+IgMhi) and An1 anergic (CD23+ IgMlo) B cells are shown. Percentages indicate B cells in the gated B220+ population. B, Bar graphs show the percentages of T1, T2 and An1 anergic B cells in the gated B220+ population. C, Bar graphs show the numbers of An1 anergic B cells in the spleens of wild-type and Bcl10-deficient mice. D, Apoptosis of splenic B cell subpopulations. Bar graphs show the degree of TUNEL labeling in T1, T2, An1 anergic and FO B cells of wild-type and Bcl10-deficient mice. Data shown are obtained from at least 7 (A, B and D) or 4 (C) mice in each group. Error bars show ± SD. *, P < 0.01; **, P = 0.02.