Plasma (A) and renal (B) ACE activities, plasma renin activity (PRA) (C), and plasma aldosterone concentration (D). A and B: Plasma ACE activity in plasma and the kidney were unchanged by Ang I infusion. Temocapril, but not olmesartan, reduced ACE activity in both plasma and kidney. C: PRA was undetectable following Ang I infusion. Temocapril and olmesartan treatment increased PRA. D: Plasma aldosterone levels were increased by Ang I infusion. Either temocapril or olmesartan treatment suppressed the increase in plasma aldosterone level. *P < 0.05 vs. vehicle-infused group, #P < 0.05 vs. Ang I + control group, n.d.: not detectable.