Table 2. Current level of DED symptoms reported by men and women with diagnosed DED.

	Women	Men	P value
	Mean (SD)	Mean (SD)
DED symptoms based on OSDI*†
Ocular Symptoms subscale	29.0 (21.6)	18.5 (18.3)	<0.0001
Vision Related Function subscale	22.0 (19.9)	17.3 (19.3)	<0.0001
Environmental Triggers subscale	35.4 (29.3)	21.2 (23.7)	<0.0001
Overall score of OSDI	26.8 (18.7)	18.2 (16.4)	<0.0001
DED symptoms based on SANDE* ‡
Frequency	48.4 (28.5)	32.4 (28.1)	<0.0001
Severity	39.4 (27.4)	24.9 (23.0)	<0.0001
Overall Score	42.3 (26.8)	27.2 (23.7)	<0.0001
How much dry eye symptoms limited daily activities§	3.2 (2.2)	2.6 (1.8)	<0.0001

^*P-values are from linear regression models adjusted for age. Age was significantly inversely associated only with the OSDI Environmental Triggers subscale (P=0.0002)

† OSDI=The Ocular Surface Disease Index, a validated questionnaire to measure symptoms of DED. Scores range from 0 (no symptoms) to 100 (maximum symptoms).

^‡SANDE=The Symptom Assessment in Dry Eye questionnaire, a validated visual analogue scale to assess ocular surface discomfort in DED. Scores range from 0 to 100 with higher scores indicating worse symptoms.

^§A single question from our questionnaire; scores ranged from 0=Not at all - 10=Severely. This P-value is from a proportional odds logistic regression model adjusted for age.