Table 3. Meta-analysis of MDM2 SNP309 polymorphism and CRC risk.

Analysis	No. of studies	Homozygote (GG vs. TT)			Heterozygote (TG vs. TT)				Dominant model (GG+TG vs. TT)				Recessive model (GG vs. TG+TT)
		OR (95% CI)	P/P h		OR (95% CI)		P/P h		OR (95% CI)		P/P h		OR (95% CI)	P/P h
Overall	14	1.086 (0.773-1.525)	0.634/0.000		1.217 (0.979-1.512)	0.077/0.000			1.176 (0.936-1.478)	0.163/0.000			0.959 (0.748-1.230)	0.743/0.000
Ethnicity
Caucasian	7	0.848 (0.643-1.118)	0.242/0.307		1.071 (0.881-1.301)	0.494/0.185			1.016 (0.844-1.223)	0.865/0.200			0.812 (0.635-1.038)	0.097/0.136
Asian	6	1.086 (0.729-1.618)	0.684/0.000		1.197 (1.055-1.358)	0.005/0.395			1.246 (1.106-1.404)	0.000/0.046			1.027 (0.729-1.447)	0.880/0.000
African	1	8.665 (4.139-18.141)	0.000/—		8.935 (4.337-18.409)	0.000/—			8.812 (4.436-17.506)	0.000/—			1.843 (1.167-2.908)	0.009/—
p53 mutation status
Positive	2	0.777 (0.426-1.418)	0.411/0.138		1.209 (0.824-1.773)	0.332/0.344			1.100 (0.768-1.575)	0.604/0.225			0.709 (0.398-1.263)	0.243/0.196
Negative	2	0.884 (0.482-1.620)	0.690/0.668		1.409 (0.956-2.075)	0.083/0.340			1.274 (0.884-1.835)	0.194/0.515			0.762 (0.429-1.352)	0.353/0.457
Gender
Female	3	1.030 (0.736-1.442)	0.862/0.206		1.003 (0.760-1.325)	0.981/0.813			1.011 (0.776-1.317)	0.937/0.936			0.898 (0.517-1.560)	0.702/0.058
Male	3	0.978 (0.727-1.317)	0.884/0.219		1.110 (0.603-2.042)	0.737/0.008			1.026 (0.601-1.753)	0.925/0.017			0.852 (0.672-1.080)	0.186/0.437
HWE in controls
Yes	9	1.054 (0.763-1.457)	0.751/0.000		1.166 (1.037-1.311)	0.010/0.261			1.124 (0.942-1.342)	0.195/0.046			0.968 (0.723-1.296)	0.829/0.000
No	5	1.186 (0.422-3.335)	0.746/0.000		1.535 (0.749-3.145)	0.241/0.000			1.421 (0.675-2.992)	0.355/0.000			0.921 (0.529-1.604)	0.771/0.002

P _h P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HWE, Hardy–Weinberg equilibrium