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. 2013 Sep 30;8(9):e75877. doi: 10.1371/journal.pone.0075877

Figure 6. Rac1 (a) was elevated in day 7 wounds (N - nondiabetic,D-diabetic; NI,DI-injury wound zone; NA,DA- adjacent to wound) [ANOVA p=0.0004; post hoc *p<0.05 for N vs. NI and D vs. DI; n=3/group].

Figure 6

RHOA (b) increased in diabetics following injury [ANOVA p<0.0001; post hoc *p<0.05 for NI vs. DI, D vs. DI; n=3/group]. PTEN (c) was elevated after injury [ANOVA p=0.0006; post hoc *p<0.05 for N vs.NI and D vs. DI; n=3/group]. PTEN was localized in subepidermal axons (arrows) and diffusely in keratinocytes and dermal connective tissue (nondiabetic intact skin (d) or adjacent to wound (e) and diabetic adjacent to wound (f)) [Bar=33 microns]. There was widespread PTEN rise in the central wound zone and adjacent skin [nondiabetic illustrated by wholemount (g) [Bar=200 microns].