Table 3. Postdiagnosis menopausal symptoms in association with breast cancer recurrence by body-mass-index (BMI), SBCSS (n=4,842).
|
BMI (universal cutoff point) |
|||||
|---|---|---|---|---|---|
| Experience with menopausal symptoms |
Overweight/obese (≥25 kg/m2) n=1,705
|
Not overweight/obese (<25 kg/m2) n=3,137
|
|||
| cases | HRa (95% CI) | cases | HRa (95% CI) | P interaction | |
| Any menopausal symptomb | |||||
| No | 815 | 1.00 (reference) | 1318 | 0.98 (0.78-1.22) | |
| Yes | 890 | 1.05 (0.83-1.33) | 1819 | 0.84 (0.67-1.04) | 0.18 |
| Hot flashes | |||||
| No | 1035 | 1.00 (reference) | 1669 | 0.95 (0.78-1.15) | |
| Yes | 670 | 1.01 (0.79-1.29) | 1468 | 0.78 (0.64-0.99) | 0.24 |
| Night sweats | |||||
| No | 1127 | 1.00 (reference) | 1999 | 0.88 (0.73-1.07) | |
| Yes | 578 | 0.95 (0.74-1.22) | 1138 | 0.82 (0.66-1.03) | 0.90 |
| Vaginal dryness | |||||
| No | 1574 | 1.00 (reference) | 2841 | 0.88 (0.75-1.03) | |
| Yes | 131 | 0.97 (0.61-1.54) | 296 | 0.86 (0.61-1.22) | 0.97 |
| No. of menopausal symptoms | |||||
| 0 | 815 | 1.00 (reference) | 1318 | 0.98 (0.78-1.22) | |
| 1 | 455 | 1.20 (0.92-1.58) | 870 | 0.85 (0.66-1.11) | |
| ≥2 | 435 | 0.88 (0.65-1.20) | 949 | 0.81 (0.62-1.05) | 0.51 |
a
HRs are adjusted for age at diagnosis (continuous), education (categories), number of pregnancies (categories), marital status, history of chronic disease (Charlson comorbidity score 0/≥1), perceived quality of life (categories), treatment received (radiotherapy, chemotherapy, immunotherapy, and/or tamoxifen; yes/no), TNM, and ER and PR status
b
Included hot flashes, night sweats, and/or vaginal dryness