Table 5. Menopausal symptoms in association with breast cancer recurrence by tamoxifen use, SBCSS (n=4,842).
|
Tamoxifen
|
|||||
|---|---|---|---|---|---|
| Experience with menopausal symptoms |
Did not use n=2,314
|
Useda n=2,093
|
|||
| cases | HRb (95% CI) | cases | HRb (95% CI) | P interaction | |
| Any menopausal symptomc | |||||
| No | 1154 | 1.00 (reference) | 791 | 0.79 (0.60-1.04) | |
| Yes | 1160 | 0.92 (0.75-1.13) | 1302 | 0.78 (0.60-1.01) | 0.82 |
| Hot flashes | |||||
| No | 1439 | 1.00 (reference) | 1029 | 0.86 (0.67-1.10) | |
| Yes | 875 | 0.96 (0.78-1.19) | 1064 | 0.75 (0.58-0.98) | 0.30 |
| Night sweats | |||||
| No | 1571 | 1.00 (reference) | 1279 | 0.77 (0.61-0.98) | |
| Yes | 732 | 0.88 (0.71-1.10) | 814 | 0.81 (0.61-1.06) | 0.59 |
| Vaginal dryness | |||||
| No | 2108 | 1.00 (reference) | 1908 | 0.83 (0.67-1.02) | |
| Yes | 206 | 0.96 (0.67-1.37) | 185 | 0.70 (0.42-1.17) | 0.58 |
| No. of menopausal symptoms | |||||
| 0 | 1154 | 1.00 (reference) | 791 | 0.79 (0.60-1.14) | |
| 1 | 585 | 0.98 (0.77-1.24) | 621 | 0.86 (0.63-1.17) | |
| ≥2 | 575 | 0.85 (0.66-1.10) | 681 | 0.71 (0.52-0.96) | 0.75 |
a
Tamoxifen use among ER+ patients only
b
HRs are adjusted for age at diagnosis (continuous), education (categories), number of pregnancies (categories), marital status, history of chronic disease (Charlson comorbidity score 0/≥1), perceived quality of life (categories), treatment received (radiotherapy, chemotherapy, and/or immunotherapy; yes/no), TNM, and ER (where appropriate) and PR status
c
Included hot flashes, night sweats, and/or vaginal dryness