Skip to main content
. 2013 Sep 30;8(9):e76210. doi: 10.1371/journal.pone.0076210

Figure 3. Quercetin attenuates chondrogenic transformation and β-catenin activation in primary VSMCs.

Figure 3

A, Quercetin reduces deposition of GAG-positive matrix in VSMCs induced to undergo chondrogensis in high-density micromass culture in chondrogenic medium (ChoM). Quantitation of GAG deposition (left graph) and cell death, detected by LDH release into the culture medium (right graph), in the presence or absence of 50 µmol/L quercetin. N=4. B-C, Real-time PCR analysis of markers of chondrogenesis (B) and β-catenin target genes (C) in VSMC micromass cultures treated with ChoM and quercetin as indicated. N=4. D, Quantitation of GAG deposition by VSMC micromass cultures treated with ChoM in the presence or absence of 0.5 µg/mL Dkk1. N=4.