Table 4. Changes in osteogenic gene expression in aortas from Mgp-/- mice treated with quercetin compared to untreated Mgp-/- aortic tissue.

Gene	Protein name	Fold Down-Regulation	p-value
AlpI	Alkaline phosphatase	-2.09**	0.032
Anxa5	Annexin 5	-1.90**	0.010
Bmpr1b	BMP receptor, type 1B	-2.94**	0.006
Col14a1	Collagen type XIV, alpha 1	-4.28**	0.008
Col1a2	Collagen type I, alpha 2	-3.18**	0.043
Col4a2	Collagen type IV, alpha 2	-2.63**	0.035
Col6a1	Collagen type VI, alpha 1	-2.53**	0.048
Col6a2	Collagen type VI, alpha 2	-3.76**	0.015
Fgf3	Fibroblast growth factor 3	-6.78**	0.002
Fgfr1	Fibroblast growth factor receptor 1	-2.19**	0.014
Itga3	Integrin alpha 3	-2.03**	0.027
Itgav	Integrin alpha V	-3.17**	0.002
Mmp8	Matrix metalloproteinase 8	-4.20**	0.051
Smad1	MAD homolog 1	-1.48**	0.017
Tgfb3	Transforming growth factor, beta 3	-2.77**	0.001
Tgfbr1	Transforming growth factor receptor, beta 1	-3.19**	0.043
Col10a1	Collagen type X, alpha 1	-8.07**	0.105
Mmp10	Matrix metallopeptidase 10	-7.06**	0.145

Tissue from 4.5 week old animals was analyzed using a qRT-PCR-based microarray N=5. *, p<0.05; ** p<0.01.