Table 5. Changes in expression of genes related to chondrogenic differentiation in Mgp-/- versus wild-type and in quercetin-treated Mgp-/- (Mgp-/- +Q) versus untreated Mgp-/- aortic tissue from 4.5 week old animals analyzed by qRT-PCR-based microarray.
| Gene | Protein | Fold change in expression | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mgp-/- to wild-type | p-value | Mgp-/- +Q to Mgp-/- | p-value | ||||||
| Extracellular matrix proteins | |||||||||
| Col11a1 | Collagen, type XI | 4.34*** | 0.005 | -3.79*** | 0.006 | ||||
| Col12a1 | Collagen, type XII | 9.86*** | 0.029 | -3.94*** | 0.031 | ||||
| Col1a1 | Collagen, type I | 7.28*** | 0.034 | -2.58*** | 0.143 | ||||
| Col2a1 | Collagen, type II | 1152.89*** | 0.015 | -22.74*** | 0.020 | ||||
| Comp | Cartilage oligomeric matrix protein | 75.92*** | 0.031 | -3.26*** | 0.058 | ||||
| Dmp1 | Dentin matrix protein 1 | 12.19*** | 0.048 | -4.52*** | 0.070 | ||||
| Fn1 | Fibronectin 1 | 4.31*** | 0.031 | -1.94*** | 0.138 | ||||
| Vcam1 | Vascular cell adhesion molecule 1 | 11.62*** | 0.015 | -2.17*** | 0.073 | ||||
| Mmp2 | Matrix metalloproteinase 2 | 3.48*** | 0.010 | -2.01*** | 0.028 | ||||
| Transcription factors | |||||||||
| Msx1 | Homeobox, msh-like 1 | 2.85*** | 0.003 | -3.66*** | <0.001 | ||||
| Runx2 | Runt related transcription factor 2 | 8.81*** | <0.001 | -2.40*** | 0.002 | ||||
| Sox9 | SRY-box containing gene 9 | 7.95*** | 0.002 | -2.24*** | 0.028 | ||||
| Twist1 | Twist homolog 1 (Drosophila) | 1.69*** | 0.040 | -2.19*** | 0.027 | ||||
| Vdr | Vitamin D receptor | 5.38*** | 0.008 | -1.03*** | 0.740 | ||||
N=5. *, p<0.05; ** p<0.01; *** p<0.001.