Table 1. Echocardiographic data.
| SHAM (n= 9) | SHAM-S (n= 9) | MI (n= 15) | MI -S (n= 15) | p MI | p S | p MIxS | |
|---|---|---|---|---|---|---|---|
| BW (g) | 486.6 ± 30.3 | 486.1 ± 31.7 | 458.5 ± 30.2 | 482.3 ± 55.2 | 0.190 | 0.336 | 0.318 |
| HR (bpm) | 298 ± 17 | 307 ± 30 | 311 ± 34 | 305 ± 29 | 0.536 | 0.811 | 0.402 |
| LVDD/BW (mm/kg) | 16.9 ± 0.9 | 16.3 ± 1.5 | 23.0 ± 2.5 | 21.8 ± 2.9 | <0.001 | 0.170 | 0.717 |
| LVSD/BW (mm/kg)* | 7.88 ± 0.9 | 6.7 ± 0.9 | 17.4 ± 2.7 | 16.1 ± 3.4 | < 0.001 | 0.019 | 0.480 |
| RWT | 0.34 ± 0.02 | 0.36 ± 0.02 | 0.29 ± 0.03 | 0.30 ± 0.03 | <0.001 | 0.162 | 0.369 |
| LVMI (g/kg)* | 1.72 ± 0.20 | 1.59 ± 0.14 | 3.29 ± 0.96 | 2.90 ± 0.58 | <0.001 | 0.151 | 0.799 |
| IRT/RR0.5 (ms) | 48.0 ± 4.8 | 52.3 ± 6.5 | 51.5 ± 12.9 | 59.8 ± 11.1 | 0.077 | 0.044 | 0.502 |
| E/A* | 1.43 ± 0.17 | 1.38 ± 0.24 | 3.92 ± 3.87 | 2.47 ± 2.21 | 0.141 | 0.507 | 0.839 |
| EDT (ms) | 38.6 ± 6.33 | 43.7 ± 7.52 | 34.8 ± 6.07 | 37.4 ± 6.88 | 0.022 | 0.076 | 0.533 |
| FAC | 73.99 ± 7.85 | 69.84 ± 4.45 | 39.00 ± 11.05 | 34.62 ± 9.37 | <0.001 | 0.120 | 0.966 |
| PWSV (mm/s) | 36.1 ± 3.92 | 33.7 ± 1.90 | 28.1 ± 3.92 | 28.6 ± 4.85 | <0.001 | 0.431 | 0.238 |
S: spironolactone; MI: myocardial infarction; BW: body weight; HR: heart rate; LVDD: LV end-diastolic dimension; LVSD: LV end-systolic dimension; RWT: relative wall thickness; LVMI: left ventricle mass index; IVRT/RR0.5: isovolumetric relaxation time corrected for heart rate; E/A: peak velocity of early ventricular filling/ peak velocity of transmitral flow during atrial contraction; EDT: E wave deceleration time; FAC: fractional area change; PWSV: posterior wall shortening velocity. * data normalized for statistical analysis.