Table 4. Odds ratios for the symptoms and findings collected in the questionnaire (independent variables) occurring in first-degree relatives, compared with the healthy control group.

	First-degree relatives vs. controls
	p-value	Odds ratio	95%-confidence interval
Female gender	0.6587	1.081	0.8	1.5
Smoker	0.0144	1.769	1.1	2.8
Abdominal pain	0.0037	2.073	1.3	3.4
Diarrhea	0.0002	2.425	1.5	3.9
Gastritis	0.0097	1.962	1.2	3.3
Meteorisms	0.0339	1.511	1.0	2.2
Nausea	0.0039	2.235	1.3	3.9
Non-cardiac chest pain	0.0719	1.981	0.9	4.2
Hypercholesterinemia	0.9907	1.002	0.7	1.5
Paresthesia/pain	0.0003	2.542	1.5	4.2
Tachycardia	0.0009	1.992	1.3	3.0
Flush	<.0001	3.807	1.9	7.5
Hot flash	<.0001	2.842	1.8	4.6
Blood pressure changes (acute)	0.0049	1.965	1.2	3.2
Thyroid dysfunction	0.5617	0.876	0.6	1.4
Diabetes mellitus	0.6074	1.194	0.6	2.4
Asthenia	<.0001	3.869	2.0	7.4
Fatigue	<.0001	2.619	1.7	4.1
Weight loss	0.1889	1.946	0.7	5.3
Angioedema	0.0531	2.286	1.0	5.4
Conjunctivitis	0.0008	2.324	1.4	3.8
Tinnitus	0.3104	1.267	0.8	2.0
Nasal congestion/rhinorrhea	0.0038	1.926	1.2	3.0
Pulmonary symptoms	0.0027	1.943	1.3	3.0
Headache	0.0120	1.719	1.1	2.6
Urticaria pigmentosa	0.2994	1.356	0.8	2.4
Urticaria	0.0111	3.481	1.3	9.6
Telangiectasia	0.7706	1.100	0.6	2.1
Rheumatic diseases	0.0410	3.578	1.0	13.2
Allergies	0.3105	1.200	0.8	1.7
Osteoporosis	0.0246	3.952	1.1	14.3
Liver affection	0.0552	2.953	0.9	9.4
Splenomegaly	0.1478	2.103*
Fibromyalgia	0.0501	6.386	0.8	53.4
Eosinophilia	0.1653	0.518*

For a number of symptoms odds ratios could not be calculated because data were not available.

^*Odds ratio estimated.