Table 2. Risk of gastric non-cardia cancer associated with serum ghrelin presented as either quintiles or continuous variable before and after adjustment for serum PG I/II ratio, H.pylori status and smoking.
Non-adjusted | Adjusted | |||||||
Cases | Controls | OR | 95% CI | P value | OR | 95% CI | P value | |
n (%) | n (%) | |||||||
Ghrelin Quintiles (pg/ml) | ||||||||
5th: 960–1098 | 3 (4.2%) | 14 (19.4%) | 1.00 | 1.00 | ||||
4th: 824–957 | 5 (6.9%) | 15 (20.8%) | 1.56 | 0.31–7.75 | 0.691 | 1.06 | 0.17–6.81 | 0.952 |
3rd: 708–818 | 10 (13.9%) | 14 (19.4%) | 3.33 | 0.75–14.76 | 0.113 | 2.65 | 0.49–14.35 | 0.257 |
2nd: 579–693 | 17 (25.0%) | 15 (20.8%) | 5.60 | 1.35–23.23 | 0.018 | 3.63 | 0.70–18.78 | 0.124 |
1st: 246–570 | 36 (50.0%) | 14 (19.4%) | 12.01 | 2.99–48.25 | <0.001 | 6.58 | 1.26–34.46 | 0.026 |
Decreasing ghrelin as continuous variable (scaled to 159 pg/ml) | 2.09 | 1.53–2.84 | <0.001 | 1.81 | 1.25–2.64 | 0.002 |