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. 2013 Sep 30;8(9):e74405. doi: 10.1371/journal.pone.0074405

Figure 5. Infusion of FGF-2 neutralizing antibody reversed functional recovery.

Figure 5

(A, B) To confirm the relationship between EE-induced FGF-2 upregulation and behavioral benefits, subgroups of EE and SC mice with HI brain injury were randomly assigned to either SC/anti-FGF-2 (n = 3) or EE/anti-FGF-2 (n = 4). (A) All animals treated with anti-FGF-2 abolished the beneficial effect on motor performance relative to EE mice not given anti-FGF-2 at 8 weeks after treatment (* p<0.05). (B). Mice treated with EE/anti-FGF-2 also showed the decreased grip strength whereas grip strength of EE mice not given anti-FGF-2 was significantly increased compared to the other groups (* p<0.05).