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. 2013 Sep 30;8(9):e74405. doi: 10.1371/journal.pone.0074405

Figure 7. Environmental enrichment also enhanced endogenous angiogenesis in the hippocampus.

Figure 7

(A, B) After exposure to EE, the capillary count and densities of PECAM-1+ cells were quantified using the MetaMorph Imaging System. Scale bar 150 μm. (A) Capillary count was increased in the dentate gyrus of the hippocampus at 8 weeks following the exposure to EE. (B) In particular, the densities of PECAM-1 in the EE mice were significantly higher than those in the SC controls at 8 weeks after treatment (* p<0.05, n = 5 each). HIE: hypoxic-ischemic encephalopathy, EE: enriched environment, SC: standard cages.