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. 2013 Sep 30;8(9):e75592. doi: 10.1371/journal.pone.0075592

Figure 2. Selective iNOS inhibition by 1400W prevents relaxin-related protection.

Figure 2

Wet-to-dry weight ratio, mean pulmonary arterial pressure (MPAP), neutrophil elastase, myeloperoxidase (MPO), and endothelin-1 in perfusate, as well as tissue malonyldialdehyde (MDA) in isolated rat lungs perfused with buffer in recirculatory mode and subjected to 90 min ischemia followed by 90 min reperfusion. Experiments (n = 6 each) were carried out in the presence of vehicle (control), 5 nM of relaxin (Rlx), the selective iNOS inhibitor 1400W (1 µ), and combinations thereof. Both 1400W (IR+1400W) and relaxin (IR+Rlx) exerted beneficial effects; when applied in the presence of 1400W relaxin did not add protection (IR+Rlx+1400W). P<0.05; *vs. control; #vs. IR.