Table 4. Performance of the four rapid diagnostic tests for the detection of pan-antigen, pLDH and aldolase, according to the Plasmodium species and test.
| Species | Target |
|
Aldolase
|
pLDH-test1
|
pLDH-test2 | pLDH-test3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| N=1237 |
|
(Now ICT Malaria)
|
(Optimal-IT)
|
(CoreMalaria) | (Palutop +4) | |||||
| All species except | Pan-antigen: | Sensitivity | 0.57 [0.41-0.74] | 0.69 [0.53-0.84] | 0.6 [0.44-0.76] | 0.63 [0.47-0.79] | ||||
| P. falciparum | pLDH | Specificity |
1 [1–1] | 1 [0.99-1] | 0.99 [0.98-1] | 0.99 [0.99-1] | ||||
| (P. ovale, | or | PPV | 0.99 [0.94-1.0] | 0.98 [0.92-1.0] | 0.94 [0.86-1.0] | 0.96 [0.89-1.0] | ||||
| P. malariae, | Aldolase | NPV | 0.52 [0.49-0.55] | 0.64 [0.61-0.67] | 0.55 [0.52-0.58] | 0.58 [0.55-0.61] | ||||
| or P. vivax) | LR+ | 343.4 | 164.9 | 60.1 [34.2-106] | 94.4 [47.3-189] | |||||
| [86.0-1371] | [68.74-395.4] | |||||||||
| LR- | 0.43 [0.29-0.63] | 0.32 [0.19-0.51] | 0.4 [0.27-0.61] | 0.37 [0.24-0.58] | ||||||
| Plasmodium | Aldolase* | pLDH-test1* | pLDH-test2* | pLDH-test3* | Cochran Q test | |||||
| species | (Now ICT Malaria) | (Optimal-IT) | (CoreMalaria) | (Palutop +4) | P value | |||||
| P. falciparum | 246/334 (73.6%) | 271/334 (81.1%) | 232/334 (69.5%) | 264/334 (78.4%) | <0.0001 | |||||
| P. ovale | 7/18 (38.9%) | 10/18 (55.6%) | 8/18 (44.4%) | 8/18 (44.4%) | 0.10 | |||||
| P. vivax | 10/11 (90.9%) | 10/11 (90.9%) | 8/11 (72.8%) | 10/11 (90.9%) | 0.31 | |||||
| P. malariae | 5/9 (55.6%) | 6/9 (66.7%) | 5/9 (55.6%) | 6/9 (66.7%) | 0.39 | |||||
*
ratio of samples positive in the test to the number of samples positive in the reference method (sensitivity)