Table 3. Multivariate Cox regression analysis of overall and disease-specific survival in melanoma patients.
| Variables | Overall Survival | Disease-specific Survival | ||||||
| ߆ | SE | HR (95% CI) | p-value | ß | SE | HR (95% CI) | p-value | |
| Training Set (5-year) | ||||||||
| Nuclear p300 | −0.549 | 0.225 | 0.59 (0.37–0.90) | .015 | −0.479 | 0.234 | 0.62 (0.39–0.98) | .040 |
| Cytoplasmic p300 | 0.275 | 0.221 | 1.32 (0.85–2.03) | .215 | 0.201 | 0.232 | 1.22 (0.78–1.92) | .387 |
| AJCC | 1.339 | 0.228 | 3.82 (2.44–5.97) | 4.3×10−9 | 1.526 | 0.242 | 4.60 (2.86–7.39) | 2.8×10−10 |
| Gender | −0.092 | 0.234 | 0.91 (0.58–1.44) | .693 | −0.135 | 0.246 | 0.87 (0.54–1.41) | .582 |
| Age | 0.253 | 0.222 | 1.29 (0.83–1.99) | .254 | 0.085 | 0.233 | 1.09 (0.69–1.72) | .715 |
| Validation Set (5-year) | ||||||||
| Nuclear p300 | −0.552 | 0.210 | 0.58 (0.38–0.87) | .009 | −0.606 | 0.222 | 0.54 (0.35–0.84) | .006 |
| Cytoplasmic p300 | 0.048 | 0.226 | 1.05 (0.67–1.63) | .833 | 0.140 | 0.244 | 1.15 (0.71–1.85) | .567 |
| AJCC | 1.287 | 0.232 | 3.62 (2.30–5.71) | 3.0×10−8 | 1.470 | 0.251 | 4.35 (2.66–7.12) | 4.6×10−9 |
| Gender | 0.465 | 0.215 | 1.59 (1.04–2.42) | .030 | 0.546 | 0.227 | 1.73 (1.11–2.69) | .016 |
| Age | 0.356 | 0.214 | 1.43 (0.94–2.13) | .096 | 0.317 | 0.226 | 1.37 (0.88–2.14) | .160 |
| Combined (5-year) | ||||||||
| Nuclear p300 | −0.548 | 0.152 | 0.58 (0.43–0.78) | 3.0×10−4 | −0.548 | 0.160 | 0.59 (0.42–0.79) | 6.0×10−4 |
| Cytoplasmic p300 | 0.163 | 0.155 | 1.18 (0.87–1.59) | .292 | 0.163 | 0.163 | 1.18 (0.85–1.62) | .317 |
| AJCC | 1.269 | 0.159 | 3.56 (2.61–4.86) | 1.4×10−15 | 1.442 | 0.170 | 4.23 (3.03–5.90) | 2.5×10−17 |
| Gender | 0.219 | 0.154 | 1.24 (0.92–1.68) | .157 | 0.234 | 0.162 | 1.26 (0.92–1.74) | .150 |
| Age | 0.326 | 0.151 | 1.38 (1.03–1.86) | .031 | 0.233 | 0.158 | 1.26 (0.93–1.72) | .141 |
| Combined (10-year) | ||||||||
| Nuclear p300 | −0.478 | 0.141 | 0.62 (0.47–0.82) | 7.0×10−4 | −0.482 | 0.152 | 0.62 (0.46–0.83) | .001 |
| Cytoplasmic p300 | 0.266 | 0.143 | 1.30 (0.98–1.73) | .063 | 0.291 | 0.156 | 1.34 (0.98–1.81) | .062 |
| AJCC | 1.074 | 0.146 | 2.93 (2.20–3.89) | 1.6×10−13 | 1.293 | 0.160 | 3.64 (2.66–4.98) | 5.7×10−16 |
| Gender | 0.081 | 0.145 | 1.08 (0.82–1.44) | .575 | 0.164 | 0.156 | 1.18 (0.87–1.60) | .291 |
| Age | 0.442 | 0.141 | 1.56 (1.18–2.05) | .002 | 0.285 | 0.151 | 1.33 (0.99–1.79) | .059 |
Coding of variables: Age was coded as 1 ((60 years), and 2 (>60 years). Gender was coded as 1 (male) and 2 (female). p300 expression was coded as 1 (neg-weak) and 2 (mod-strong). AJCC staging was coded as 1 (stages I & II), and 2 (stages III & IV).
†
ß: regression coefficient.
Abbreviations: SE, standard error of ß; HR, hazard ratio; CI, confidence interval.