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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: J Immunol. 2013 Sep 15;191(6):2857–2863. doi: 10.4049/jimmunol.1301539

Table 1. Inflammatory Triggers, Signaling and Associated Diseases.

Trigger Senor + signaling
pathway		 Associated diseases References
Nuclear proteins

  • HMGB1

  • TLR2/4

  • RAGE

  • CD24

  • Acute kidney injury

  • Acute hepatic injury

  • Acute allograft rejection

 (7-10, 72)
   Mitochondrial
    components

  • Formylated peptides

  • DNA

  • ATP

  • FPR1

  • TLR9

  • ATP in combination with NLRP3

  • Crush injury/trauma

  • Acute hepatic injury

  • Acute kidney injury (ATP + NLRP3)

 (10-12, 73)
Monosodium uric acid
crystals

  • IL-1receptor + MyD88

  • NLP3

  • Gout

  • Acute lung injury induced by bleomycin

 (19, 20, 22,
74)
Components of
extracellular matrix

  • Hyaluronan

  • TLR2/4

  • CD44

  • Acute lung injury induced by bleomycin

 (17, 18, 75)
Cholesterol

  • NLRP3

  • Atherosclerosis

 (44)
Particles

  • Silica

  • Asbestos

  • NLRP3

  • Lung fibrosis

 (49)
IL-1α

  • IL-1 receptor

  • Acute allograft rejection

 (54)