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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Cancer Res. 2012 Oct 15;72(24):6425–6434. doi: 10.1158/0008-5472.CAN-12-1728

Figure 6. Somatic Trp53 mutations in radiation-induced tumors.

Figure 6

A. Table summarizing mutational spectrum in Trp53. Mouse genotype refers to the genotype of the animal from which the tumor was isolated. WT – wildtype, HET – Nf1 mutant. Using the COSMIC database we found that these mutations also are found in human tumors (COSMIC ID number/mutation). LOH of the B6-derived Trp53 allele (B6), or LOH of the Sv129-derived Trp53 allele (129) is noted for each mutation. B. Sequencing chromatogram from a tail control and radiation-induced tumor showing somatic deletion(Δ) in exon 7. C. Schematic of p53 exons showing localization of identified mutations.